While studying at the institute, Mendelsohn began his friendship with American Chef Marcel Vigneron. In 2005, Mendelsohn graduated from the Culinary Institute of America. Young Mendelsohn worked at Pepin as 'busboy, dishwasher, pinch-hitting as a cook when short staffed.' Petersburg, Florida until its sale in 2004. Later, the family moved to Clearwater Beach, Florida. The family resided there for three and a half years, during which time he attended school in Marbella, Spain. In 1993, when Mendelsohn was thirteen years old, his family moved to Seville, Spain. His mother is Greek and his father is Jewish. Mendelsohn was born in Montreal, Quebec, Canada. In 2019, Mendelsohn opened PLNT Burger, a vegan restaurant featuring Beyond Meat, inside Whole Foods Market in Silver Spring, Maryland. In the summer of 2017, Mendelsohn closed his restaurant Béarnaise in Washington's Capitol Hill and opened Santa Rosa Taqueria in its place. He is the chef and owner of multiple restaurants: Good Stuff Eatery, Santa Rosa Taqueria, and We, The Pizza in Washington, D.C. Evangelos Spiros 'Spike' Mendelsohn (born December 15, 1980) is a Washington, D.C.-based chef and restaurateur best known as the fifth-place finisher of the fourth season of Top Chef, which aired 2008–2009.

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